| Item Type | Name |
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Concept
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Protein-Tyrosine Kinases
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Concept
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Protein Binding
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Protein Processing, Post-Translational
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Concept
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Adaptor Protein Complex alpha Subunits
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Concept
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Proto-Oncogene Protein c-fli-1
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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Adaptor Protein Complex 2
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Concept
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Oncogene Protein p21(ras)
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Concept
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Protein Kinase Inhibitors
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Concept
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Mitogen-Activated Protein Kinase 1
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Concept
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Protein Biosynthesis
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Concept
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Protein Interaction Mapping
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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Protein Kinases
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Concept
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Protein Interaction Domains and Motifs
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Concept
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Protein Tyrosine Phosphatase, Non-Receptor Type 11
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Concept
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rhoA GTP-Binding Protein
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Concept
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ets-Domain Protein Elk-1
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Concept
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RNA-Binding Protein EWS
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Concept
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Protein Structure, Secondary
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Concept
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Ubiquitin-Protein Ligases
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Concept
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Protein Kinase C
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Concept
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Protein Structure, Tertiary
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Concept
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Protein Multimerization
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Concept
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rac1 GTP-Binding Protein
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Concept
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Receptor Protein-Tyrosine Kinases
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Concept
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JNK Mitogen-Activated Protein Kinases
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Concept
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Protein Isoforms
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Concept
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Protein Conformation
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Concept
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cdc42 GTP-Binding Protein
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Concept
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Protein Engineering
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Academic Article
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axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
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Academic Article
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Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization.
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Academic Article
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Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis.
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Academic Article
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The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage.
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Academic Article
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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
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Academic Article
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Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.
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Academic Article
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Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family.
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Academic Article
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The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor.
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Academic Article
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Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells.
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Academic Article
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Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.
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Academic Article
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Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways.
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Academic Article
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The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
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Academic Article
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Mitogenesis and endocytosis: What's at the INTERSECTIoN?
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Academic Article
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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.
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Academic Article
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Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel.
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Academic Article
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The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination.
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Academic Article
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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.
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Academic Article
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The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors.
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Academic Article
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N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effects.
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Academic Article
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Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation.
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Academic Article
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The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin.
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Academic Article
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Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
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Academic Article
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Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin.
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Academic Article
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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase.
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Academic Article
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Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway.
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Academic Article
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The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition.
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Academic Article
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Bimolecular fluorescence complementation.
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Academic Article
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Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.
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Academic Article
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Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
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Academic Article
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Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.
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Academic Article
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A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2?) regulation.
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Academic Article
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Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways.
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Academic Article
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Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.
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Academic Article
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UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.
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Academic Article
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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.
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Academic Article
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Intersectin scaffold proteins and their role in cell signaling and endocytosis.
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Academic Article
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Targeting the a4-a5 interface of RAS results in multiple levels of inhibition.
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Academic Article
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Direct inhibition of RAS: Quest for the Holy Grail?
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Academic Article
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Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.
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Academic Article
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Pharmacological targeting of RAS: Recent success with direct inhibitors.
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Academic Article
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Therapeutic targeting of RAS: New hope for drugging the "undruggable".
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Academic Article
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation.
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Academic Article
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Probing RAS Function with Monobodies.
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Academic Article
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Inhibition of RAS: proven and potential vulnerabilities.
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Concept
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Protein Interaction Maps
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Concept
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Huntingtin Protein
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Concept
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Concept
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Src Homology 2 Domain-Containing, Transforming Protein 2
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Concept
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Src Homology 2 Domain-Containing, Transforming Protein 3
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